Which animals are most likely to give the closest representation to how a drug would work inside us?

Question: Which animals are most likely to give the closest representation to how a drug would work inside us?

Asked by walkercrispman to Michelle, Duncan, Lori-An, Deuan, Darren on 22 Jun 2010 in Categories: Your Research. This question was also asked by shannonc.
- Michelle Hudson-Shore answered on 18 Jun 2010:
  
  It depends on the disease and the functions in the body that it affects so it has to be assessed on a case by case basis.
  Ultimately the best way to see how a drug works is to test it on humans.
- Darren Nesbeth answered on 18 Jun 2010:
  
  Humanised Mice.
- Lori-An Etherington answered on 22 Jun 2010:
  
  This is a good question, different animals have been shown to represent certain human characteristics – one example is that rabbits are used as a safety test to see how drugs affect the heart rhythm as it apparently is the best approximation of humans in this respect. In the UK over three quarters of the animals used in research are mice or other rodents. There is a very good website which has a lot of information on this topic and I will paste the link below:
  
  http://www.understandinganimalresearch.org.uk
  
  Hope this helps

Question: Which animals are most likely to give the closest representation to how a drug would work inside us?